He may not have even started, but Harry Kane is definitely out of tomorrow's game with a broken nose as Pochettino plays it safe with his star striker ahead of three Premier League games in the space of seven days.
Erik Lamela is Spurs' only player with Serie A experience from his previous club Roma and the Argentine is expected to return from illness and could start ahead of Alli if Pochettino wants to give the teenager - booked in the first leg for a rash off-the-ball reaction - a rest and not risk him being suspended for the next round.
Ryan Mason could start in midfield with Moussa Dembele and Tom Carroll expected to miss out with groin and calf problems respectively.
Fiorentina have no new injury worries and are likely to name a similar starting XI to the one that lined up against Spurs last week.
Hugo Lloris has recovered from his shoulder injury but expect Michel Vorm to keep goal again and Lloris to then make his return in Sunday's visit of Swansea City.
Spurs possible starting lineup:
Vorm; Trippier, Alderweireld, Wimmer, Davies; Dier, Mason; Lamela, Eriksen, Son; Chadli
Fiorentina possible starting lineup:
Tatarusanu; Tomovic, Gonzalo, Astori, Alonso, Blaszczykowski, Costa, Borja Valero, Bernardeschi; Ilicic,
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